Precision regimen for personalized pancreatic cancer therapy
نویسندگان
چکیده
منابع مشابه
Precision Medicine for Personalized Cancer Therapy.
Precision medicine is defined as the tailoring of clinical strategies based on genomic, genetic, behavioral and environment background of individual patients. Statistics indicated that traditional clinical practices sometimes lead to poor health outcomes and a waste of medical resources. Medical waste due to unnecessary treatment or ineffective treatment amounted to 75 billion US dollars per ye...
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Purpose: Personalized medicine strategies using genomic profiling are particularly pertinent for pancreas cancer. The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) trial was initially designed to exploit results from genome sequencing of pancreatic cancer under the auspices of the International Cancer Genome Consortium (ICGC) in Australia. Sequencing revealed small subsets of pati...
متن کاملpharmacogenetics and personalized medicine in pancreatic cancer
pancreatic cancer (pc) is a progressive, fatal disease with a high degree of malignancy. more than 40000 peoplediefrom this cancer annually in the united states. as a multifactorial condition, pc has a complex nature, and there are several genes and signalingpathwaysimplicated in pc pathogenesis and progression. there are diffèrent mutations in master genesincludingtumorsuppressors and oncogene...
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Trastuzumab (Herceptin), a monoclonal antibody directed against the human epidermal growth-factor receptor 2 (HER2), is the poster child for antibody-based targeted therapy in breast cancer. Pertuzumab, another humanized monoclonal antibody, binds to a different domain of HER2 and prevents the formation of HER2:HER3 dimers, which is the most potent heterodimer in the HER family. The combination...
متن کاملPersonalized RNA Medicine for Pancreatic Cancer.
Purpose: Since drug responses vary between patients, it is crucial to develop pre-clinical or co-clinical strategies that forecast patient response. In this study, we tested whether RNA-based therapeutics were suitable for personalized medicine by using patient-derived-organoid (PDO) and patient-derived-xenograft (PDX) models.Experimental Design: We performed microRNA (miRNA) profiling of PDX s...
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ژورنال
عنوان ژورنال: Precision Radiation Oncology
سال: 2017
ISSN: 2398-7324
DOI: 10.1002/pro6.19